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Rhodium-Catalyzed Transformations of Diazo Compounds Via a Carbene-Based Strategy: Recent Advances Publisher

Summary: Can diazo compounds create new drugs? Research shows they help build diverse molecules for medicines, advancing synthetic chemistry for treatments. #DrugSynthesis #Chemistry

Doraghi F1 ; Baghershahi P2 ; Ghasemi M3 ; Mahdavi M1 ; Alharrasi A3
Authors

Source: RSC Advances Published:2024


Abstract

Diazo compounds are known to be good coupling partners in the synthesis of heterocycles, carbocycles and functionalized molecules via a rhodium carbene-based strategy. Many heterocyclic and carbocyclic compounds, including isoquinolones and isocoumarins, quinoxalines, indoles, pyrrones, benzothazines, enaminones, benzenes and seven-membered rings, can be constructed using this rhodium-catalyzed system. The reaction mechanism involves C-H activation, carbene insertion and an annulation/functionalization sequence. This review describes the progress made in the last five years in rhodium-catalyzed transformations of diazo compounds as easily accessible precursors in organic chemistry. © 2024 The Royal Society of Chemistry.
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