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Combined Isocyanide-Based Multi-Component Ullmann-Type Reaction: An Efficient Access to Novel Nitrogen-Containing Pentacyclic Compounds Publisher Pubmed



Dianat S1 ; Mahdavi M2 ; Moghimi S2 ; Mouradzadegun A1 ; Shafiee A2 ; Foroumadi A2
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Source: Molecular Diversity Published:2015


Abstract

2-Chloro-3-formyl quinoline has been applied as an aldehyde moiety in the Groebke–Blackburn–Bienayme multi-component reaction with isocyanides, 2-aminoazines, and 2-aminoazole to afford the desired adducts which are amenable for further cyclization on the basis of Ullmann-type coupling. The copper iodide-mediated intramolecular C–N bond formation in the second step gave an easy access to a series of imidazo[4′,5′:4,5]pyrrolo[2,3-b]quinoline derivatives in moderate to good yields. © 2015, Springer International Publishing Switzerland.
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