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Synthesis of Highly Functionalized Organic Compounds Through Ugi Post-Transformations Started From Propiolic Acids Publisher Pubmed



Mohammadikhanaposhtani M1 ; Jalalimanesh N2 ; Saeedi M3, 4 ; Larijani B2 ; Mahdavi M2
Authors

Source: Molecular Diversity Published:2020


Abstract

Abstract: The Ugi four-component (Ugi-4CR) post-transformation reactions have emerged as a prominent tool to construct complex organic molecules utilizing readily available starting materials. Propiolic acid derivatives are promising choice of substrates due to their versatile reactivity. Over the last decade, Ugi post-transformations starting from propiolic acid derivatives have experienced a rapid growth to afford atom-efficient processes and enantioselective transformations. This review has focused on the recent advances in the Ugi post-transformations starting from propiolic acids and their application for the preparation of highly functionalized organic compounds. Graphic abstract: [Figure not available: see fulltext.]. © 2019, Springer Nature Switzerland AG.