Post-Ugi Cyclization Approach for Transition Metal-Free Synthesis of Azetidine Derivatives

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Post-Ugi Cyclization Approach for Transition Metal-Free Synthesis of Azetidine Derivatives Publisher

Yazzaf R¹ ; Sayahi MH² ; Mahdavi M³

Source: Tetrahedron Letters Published:2025

Abstract

A novel, metal-free strategy has been developed for the efficient synthesis of unique azetidine derivatives via a post-Ugi cyclization. This method involves generating 4-component Ugi adducts by reacting aldehydes, isocyanides, primary propargylamine, and 2-(phenylamino) benzoic acid. In the subsequent post-Ugi cyclization, azetidine derivatives are synthesized through a nucleophilic attack of a carbanion on the alkyne, followed by an intramolecular cyclization that forms a new carbon‑carbon bond. © 2025

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Style	Citing Format
MLA	Yazzaf R, Sayahi MH, Mahdavi M. "Post-Ugi Cyclization Approach for Transition Metal-Free Synthesis of Azetidine Derivatives." Tetrahedron Letters, vol. 158, no. , 2025, pp. -.
APA	Yazzaf R, Sayahi MH, Mahdavi M (2025). Post-Ugi Cyclization Approach for Transition Metal-Free Synthesis of Azetidine Derivatives. Tetrahedron Letters, 158(), -.
Chicago	Yazzaf R, Sayahi MH, Mahdavi M. "Post-Ugi Cyclization Approach for Transition Metal-Free Synthesis of Azetidine Derivatives." Tetrahedron Letters 158, no. (2025): -.
Harvard	Yazzaf R, Sayahi MH, Mahdavi M (2025) 'Post-Ugi Cyclization Approach for Transition Metal-Free Synthesis of Azetidine Derivatives', Tetrahedron Letters, 158(), pp. -.
Vancouver	Yazzaf R, Sayahi MH, Mahdavi M. Post-Ugi Cyclization Approach for Transition Metal-Free Synthesis of Azetidine Derivatives. Tetrahedron Letters. 2025;158():-.
BibTex	@article{ author = {Yazzaf R and Sayahi MH and Mahdavi M}, title = {Post-Ugi Cyclization Approach for Transition Metal-Free Synthesis of Azetidine Derivatives}, journal = {Tetrahedron Letters}, volume = {158}, number = {}, pages = {-}, year = {2025} }
RIS	TY - JOUR AU - Yazzaf R AU - Sayahi MH AU - Mahdavi M TI - Post-Ugi Cyclization Approach for Transition Metal-Free Synthesis of Azetidine Derivatives JO - Tetrahedron Letters VL - 158 IS - SP - EP - PY - 2025 ER -

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