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Recent Progress in Transformations of Azepine/Oxazepine/Thiazepine Derivatives Publisher

Summary: Can new compounds lead to drugs? Research shows dibenzoazepine derivatives create bioactive molecules, advancing drug discovery efforts. #DrugDevelopment #OrganicChemistry

Doraghi F1 ; Ameli M2 ; Karimian S3 ; Larijani B1 ; Mahdavi M1
Authors

Source: ChemistrySelect Published:2024


Abstract

Dibenzoazepine, dibenzoxazepine and dibenzothiazepine scaffolds are an important class of N-heterocycles that possess multiple biological activities. Due to the widespread application of these motifs in drug discovery, the synthesis of tri-cyclic seven-membered imines/amines has gained huge attention of chemists. In the present review, we have highlighted recent advances in functionalization and cyclization reactions of these valuable organic compounds over the last six years. © 2024 Wiley-VCH GmbH.
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