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Recent Advances in the Use of 2-Aminobenzyl Alcohols in the Synthesis of Quinolines, Quinazolines and Other N-Heterocycles Publisher

Summary: Why are quinolines important in medicine? A study highlights how 2-aminobenzyl alcohols simplify creating key compounds like quinolines for drugs, opening new treatment possibilities. #MedicinalChemistry #DrugDevelopment

Doraghi F1 ; Gilaninezhad F2 ; Karimian S3 ; Mahdavian AM1 ; Larijani B1 ; Mahdavi M1
Authors

Source: Advanced Synthesis and Catalysis Published:2024


Abstract

N-Heterocyclic compounds, in particular, quinolines and quinazolines are frequently used in medicinal chemistry. Therefore, the direct and clean synthesis of these valuable scaffolds has been a great interest for many years. 2-Aminobenzyl alcohols as an alternative reactant instead of unstable and expensive 2-aminobenzaldehydes can be used in the construction of N-fused heterocycles including quinolines, quinazolines, oxazines, thiazines, selenazines, imidazoles, diazepines, etc. In this review article, we have discussed recent developments in the use of 2-aminobenzyl alcohols in the synthesis of diverse heterocycles. © 2024 Wiley-VCH GmbH.
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