Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Solubility of 5-Aminosalicylic Acid in {N-Methyl-2-Pyrrolidone + Ethanol} Mixtures at T = (293.2 to 313.2) K Publisher



Moradi M1 ; Mazaher Haji Agha E2 ; Hemmati S2 ; Martinez F3 ; Kuentz M4 ; Jouyban A5, 6
Authors

Source: Journal of Molecular Liquids Published:2020


Abstract

The solubility determination of 5-aminosalicylic acid (mesalazine) in the N-methyl-2-pyrrolidone (NMP)/ethanol mixtures was carried out at T = (293.2 to 313.2) K. The solubility data were represented by the Jouyban-Acree, NRTL and UNIQUAC models. Apparent thermodynamic quantities for mesalazine dissolved in NMP/ethanol mixtures were determined. To discuss solute-solvent interactions in the present system, the activity coefficient values for mesalazine were computed. The results revealed that the solubility increases by addition of NMP and reaches a maximum value at neat NMP which is consistent with the minimum values of both Gibbs free energy of dissolution and mesalazine activity coefficient observed at neat NMP. Moreover, this drug is preferentially solvated by ethanol in ethanol-rich mixtures but preferential solvation by NMP in NMP-rich mixtures is observed. © 2020 Elsevier B.V.
Related Docs
View other Related Docs
1. Solubility of 5-Aminosalicylic Acid in N-Methyl-2-Pyrrolidone + Water Mixtures at Various Temperatures, Journal of Molecular Liquids (2020)
2. Solubility of Mesalazine in {1-Propanol/Water} Mixtures at Different Temperatures, Journal of Molecular Liquids (2020)
3. Solubility and Thermodynamic Properties of Mesalazine in {2-Propanol + Water} Mixtures at Various Temperatures, Journal of Molecular Liquids (2020)
Experts (# of related papers)
Alireza Foroumadi (1)
Other Related Docs
4. Solubility of Mesalazine in {Acetonitrile + Water} Mixtures at Various Temperatures, Physics and Chemistry of Liquids (2021)
5. Measurement and Modelling of the Solubility for Ketoconazole in {Acetonitrile + Water} Mixtures at T = (293.2 to 313.2) K, Physics and Chemistry of Liquids (2021)
6. The Solubility of Ketoconazole in Binary Carbitol + Water Mixtures at T = (293.2–313.2) K, Journal of Molecular Liquids (2020)
7. Simulation of Mesalazine Solubility in the Binary Solvents at Various Temperatures, Journal of Molecular Liquids (2022)
8. Solubility of Ketoconazole in 1,4-Dioxane + Water Mixtures at T = (293.2 to 313.2) K, Journal of Molecular Liquids (2020)
9. Mesalazine Solubility in the Binary Mixtures of Ethanol and Water at Various Temperatures, Physics and Chemistry of Liquids (2021)
10. A Laser Monitoring Technique for Determination of Mesalazine Solubility in Propylene Glycol and Ethanol Mixtures at Various Temperatures, Journal of Molecular Liquids (2020)
11. Mesalazine Solubility in Propylene Glycol and Water Mixtures at Various Temperatures Using a Laser Monitoring Technique, Journal of Molecular Liquids (2020)
12. Solubility of Mesalazine in Polyethylene Glycol 400 + Water Mixtures at Different Temperatures, Journal of Molecular Liquids (2020)
13. Dissolution Thermodynamics and Preferential Solvation of Ketoconazole in Some {Ethanol (1) + Water (2)} Mixtures, Journal of Molecular Liquids (2020)
14. Further Numerical Analyses on the Solubility of Diazepam in Aqueous Tert-Butanol Mixtures, Physics and Chemistry of Liquids (2021)
15. Solubility of Meloxicam in (Carbitol® + Water) Mixtures: Determination, Correlation, Dissolution Thermodynamics and Preferential Solvation, Journal of Molecular Liquids (2021)
16. Predicting the Solubility, Thermodynamic Properties and Preferential Solvation of Sulphamethazine in {Acetonitrile + Water} Mixtures Using a Minimum Number of Experimental Data Points, Physics and Chemistry of Liquids (2021)
17. Solubilisation of Dexamethasone: Experimental Data, Co-Solvency and Polarised Continuum Modelling, Physics and Chemistry of Liquids (2021)
18. Preferential Solvation of Some Corticosteroids in {Ethanol (1) + Water (2)} Mixtures at 298.2 K, Journal of Molecular Liquids (2020)
19. Further Comments on “Experimental Measurements, Equilibrium Study and Model Correlation of Methyl Paraben in Ethanol and Methanol Aqueous Solutions From = (293.15 to 323.15) K”, Journal of Molecular Liquids (2020)
20. Solubilization of Naproxen: Experimental Data and Computational Tools, Journal of Molecular Liquids (2019)