Solubilisation of Dexamethasone: Experimental Data, Co-Solvency and Polarised Continuum Modelling

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):

Share By

Solubilisation of Dexamethasone: Experimental Data, Co-Solvency and Polarised Continuum Modelling Publisher

Maheri A¹ ; Ghanbarpour P² ; Rahimpour E³ ; Jouyban A^{5, 6} ; Azarbayjani AF^{7, 8} ; Kouhkan M⁹

Source: Physics and Chemistry of Liquids Published:2021

Abstract

Experimental solubility of dexamethasone was obtained in binary aqueous mixtures of ethanol, methanol and acetonitrile at 298.2 K. The effects of micellization and pH were also investigated on the solubility of the drug. Experimental solubility data in the binary solvent mixtures were correlated by three co-solvency models, i.e. Yalkowsky, CNIBS/R-K, and the modified Wilson model. A new principle has also been investigated with the purpose of modelling drug solubility in the binary solvent mixtures using Polarised Continuum Model (PCM) by using the hybrid functional B3LYP method and 6–311++G** basis set. By matching experimental data with PCM modelling, we investigated the outcome of drug solubility in various mass fractions of binary solvent mixtures. Here we report the solute-solvent interaction energy as free energy of solvation (∆Gsol), total electrostatic energy, dipole moment, total Gibbs-free energy and dielectric constant (ε) of dexamethasone in various mass fractions of ethanol + water mixtures. © 2020 Informa UK Limited, trading as Taylor & Francis Group.

Related Docs

View other Related Docs

1. Trained Models for Solubility Prediction of Drugs in Acetonitrile + Water Mixtures at Various Temperatures, Physics and Chemistry of Liquids (2021)

2. Simulation of Mesalazine Solubility in the Binary Solvents at Various Temperatures, Journal of Molecular Liquids (2022)

3. Solubilization of Naproxen: Experimental Data and Computational Tools, Journal of Molecular Liquids (2019)

Experts (# of related papers)

Alireza Foroumadi (1)

Other Related Docs

4. Solubility of Mesalazine in {Acetonitrile + Water} Mixtures at Various Temperatures, Physics and Chemistry of Liquids (2021)

5. Computational Tools for Solubility Prediction of Celecoxib in the Binary Solvent Systems, Journal of Molecular Liquids (2020)

6. Further Comments on “Experimental Measurements, Equilibrium Study and Model Correlation of Methyl Paraben in Ethanol and Methanol Aqueous Solutions From = (293.15 to 323.15) K”, Journal of Molecular Liquids (2020)

7. Solubility and Thermodynamic Properties of Mesalazine in {2-Propanol + Water} Mixtures at Various Temperatures, Journal of Molecular Liquids (2020)

8. Solubilization of Bosentan Using Ethanol As a Pharmaceutical Cosolvent, Journal of Molecular Liquids (2017)

9. Mesalazine Solubility in the Binary Mixtures of Ethanol and Water at Various Temperatures, Physics and Chemistry of Liquids (2021)

10. Solubility of Mesalazine in {1-Propanol/Water} Mixtures at Different Temperatures, Journal of Molecular Liquids (2020)

11. The Solubility of Ketoconazole in Binary Carbitol + Water Mixtures at T = (293.2–313.2) K, Journal of Molecular Liquids (2020)

12. Measurement and Modelling of the Solubility for Ketoconazole in {Acetonitrile + Water} Mixtures at T = (293.2 to 313.2) K, Physics and Chemistry of Liquids (2021)

13. Predicting the Solubility, Thermodynamic Properties and Preferential Solvation of Sulphamethazine in {Acetonitrile + Water} Mixtures Using a Minimum Number of Experimental Data Points, Physics and Chemistry of Liquids (2021)

14. Solubility of Caffeine in N-Methyl-2-Pyrrolidone + Ethanol Mixture at Different Temperatures, Journal of Molecular Liquids (2020)

15. Solubility of 5-Aminosalicylic Acid in {N-Methyl-2-Pyrrolidone + Ethanol} Mixtures at T = (293.2 to 313.2) K, Journal of Molecular Liquids (2020)

16. Solubility of Sildenafil Citrate in the Binary Mixtures of Ethylene Glycol and Water at Different Temperatures, Journal of Molecular Liquids (2020)

17. Solubility of Caffeine in Carbitol + Ethanol Mixture at Different Temperatures, Journal of Molecular Liquids (2020)

18. A Laser Monitoring Technique for Determination of Mesalazine Solubility in Propylene Glycol and Ethanol Mixtures at Various Temperatures, Journal of Molecular Liquids (2020)

19. Preferential Solvation of Some Corticosteroids in {Ethanol (1) + Water (2)} Mixtures at 298.2 K, Journal of Molecular Liquids (2020)

20. Solubility of 5-Aminosalicylic Acid in N-Methyl-2-Pyrrolidone + Water Mixtures at Various Temperatures, Journal of Molecular Liquids (2020)

Style	Citing Format
MLA	Maheri A, et al.. "Solubilisation of Dexamethasone: Experimental Data, Co-Solvency and Polarised Continuum Modelling." Physics and Chemistry of Liquids, vol. 59, no. 6, 2021, pp. 817-826.
APA	Maheri A, Ghanbarpour P, Rahimpour E, Jouyban A, Azarbayjani AF, Kouhkan M (2021). Solubilisation of Dexamethasone: Experimental Data, Co-Solvency and Polarised Continuum Modelling. Physics and Chemistry of Liquids, 59(6), 817-826.
Chicago	Maheri A, Ghanbarpour P, Rahimpour E, Jouyban A, Azarbayjani AF, Kouhkan M. "Solubilisation of Dexamethasone: Experimental Data, Co-Solvency and Polarised Continuum Modelling." Physics and Chemistry of Liquids 59, no. 6 (2021): 817-826.
Harvard	Maheri A et al. (2021) 'Solubilisation of Dexamethasone: Experimental Data, Co-Solvency and Polarised Continuum Modelling', Physics and Chemistry of Liquids, 59(6), pp. 817-826.
Vancouver	Maheri A, Ghanbarpour P, Rahimpour E, Jouyban A, Azarbayjani AF, Kouhkan M. Solubilisation of Dexamethasone: Experimental Data, Co-Solvency and Polarised Continuum Modelling. Physics and Chemistry of Liquids. 2021;59(6):817-826.
BibTex	@article{ author = {Maheri A and Ghanbarpour P and Rahimpour E and Jouyban A and Azarbayjani AF and Kouhkan M}, title = {Solubilisation of Dexamethasone: Experimental Data, Co-Solvency and Polarised Continuum Modelling}, journal = {Physics and Chemistry of Liquids}, volume = {59}, number = {6}, pages = {817-826}, year = {2021} }
RIS	TY - JOUR AU - Maheri A AU - Ghanbarpour P AU - Rahimpour E AU - Jouyban A AU - Azarbayjani AF AU - Kouhkan M TI - Solubilisation of Dexamethasone: Experimental Data, Co-Solvency and Polarised Continuum Modelling JO - Physics and Chemistry of Liquids VL - 59 IS - 6 SP - 817 EP - 826 PY - 2021 ER -

Science Communicator Platform

Authors

Abstract