Solubilization of Bosentan Using Ethanol As a Pharmaceutical Cosolvent Publisher



Sajediamin S¹ ; Barzegarjalali M² ; Fathiazarbayjani A³ ; Kebriaeezadeh A⁴ ; Martinez F⁵ ; Jouyban A^{1, 6}
Source: Journal of Molecular Liquids Published:2017

Abstract

Solubility of bosentan in ethanol + water mixtures was experimentally determined at five different temperatures (293.2–313.2 K) with respect to the composition of the solvent mixture. Results indicate an ethanol and temperature dependent increase in bosentan solubility. Thermodynamic properties of the solution process were calculated using van't Hoff and Gibbs equations. Generated solubility data were correlated with a number of cosolvency models and the accuracies of the predicted solubilities and model performance were illustrated by mean percentage deviation (MPD). The obtained MPD values for cosolvency models trained using whole data points varied between 5.8 and 46.2%. © 2017 Elsevier B.V.