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Preferential Solvation of Some Corticosteroids in {Ethanol (1) + Water (2)} Mixtures at 298.2 K Publisher



Jouyban A1, 2 ; Martinez F4
Authors

Source: Journal of Molecular Liquids Published:2020


Abstract

The equilibrium solubility of three corticosteroids, namely, budesonide, hydrocortisone and prednisolone in some {ethanol (1) + water (2)} mixtures as expressed in mole fraction at 298.2 K was calculated from reported solubility values expressed in molarity scale. Further, by using the inverse Kirkwood-Buff integrals is observed that these drugs are preferentially solvated by water molecules in water-rich mixtures and apparently also in ethanol-rich mixtures but preferentially solvated by ethanol molecules in mixtures of similar proportions of the solvents. © 2020 Elsevier B.V.
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