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Solubility of Mesalazine in {Acetonitrile + Water} Mixtures at Various Temperatures Publisher



Barzegarjalali M1 ; Mazaher Haji Agha E2 ; Adibkia K1 ; Hemmati S3 ; Martinez F4 ; Jouyban A5, 6
Authors

Source: Physics and Chemistry of Liquids Published:2021


Abstract

The solubility of mesalazine in {acetonitrile + water} mixtures was reported at T = (293.2–313.2) K and correlated with some cosolvency models namely van’t Hoff, Apelblat, Jouyban-Acree, Jouyban-Acree-van’t Hoff, combined nearly ideal binary solvent/Redlich-Kister, modified Wilson, NRTL and UNIQUAC models. The Yalkowsky and extended Yalkowsky models were employed to predict the solubility data. The apparent thermodynamic quantities of dissolution and mixing for mesalazine in aqueous acetonitrile solutions were computed. Finally, preferential solvation analysis demonstrates that mesalazine is preferentially solvated by water in almost all the mixtures, except in the region 0.19 < x 1 < 0.29. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
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