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Solubility of Ketoconazole in 1,4-Dioxane + Water Mixtures at T = (293.2 to 313.2) K Publisher



Barzegarjalali M1, 7 ; Mazaher Haji Agha E2 ; Adibkia K1, 7 ; Martinez F3 ; Kuentz M4 ; Jouyban A5, 6, 7
Authors

Source: Journal of Molecular Liquids Published:2020


Abstract

The solubility of ketoconazole was measured in aqueous mixtures of 1,4-dioxane at T = (293.2 to 313.2) K using the shake flask method. To mathematically represent the generated solubility data, combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K), van't Hoff, Jouyban-Acree, Jouyban-Acree-van't Hoff, UNIQUAC, and NRTL models were applied. Differences of experimental and predicted values were expressed as the percentage of averaged relative deviation (% ARD). Apparent thermodynamic quantities of ketoconazole dissolution and mixing were reported at harmonic temperature. Moreover, the dissolution mechanism of ketoconazole was studied in 1,4-dioxane + water mixtures. Based on the inverse Kirkwood-Buff integrals, the preferential solvation parameters were calculated and it is observed that ketoconazole is preferentially solvated by water in water-rich and 1,4-dioxane-rich mixtures. © 2018 Elsevier B.V.
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