Tehran University of Medical Sciences

Science Communicator Platform

Faculty Members have conducted research related to the Targeting the Tlr4 Signaling Pathway by Polyphenols: A Novel Therapeutic Strategy for Neuroinflammation
Ghorbangol Ashabi
Ghorbangol Ashabi

Associate Professor of Physiology

Department Physiology

School of Medicine

Tehran University of Medical Sciences

All Documents
1. The Efficacy of Sericin in Modulating Antioxidant Enzymes and Dopaminergic D1 and D2 Receptors in a Parkinson’S Disease Animal Model, Iranian Journal of Science (2026)
2. Dose-Dependent Modulation of Nmda Receptors: Neuroprotective Mechanisms Against Oxidative Stress in Hippocampal Neurons, International Journal of Molecular and Cellular Medicine (2025)
3. Nanoliposomal Quercetin Reduces Neuroinflammation and Influences Tlr4 and Microglial Activity With Potential Effects on Gabaa2 Receptors in a Rat Model of Huntington's Disease, Brain Research Bulletin (2025)
4. Significance of Neurotransmitters in Cerebral Ischemia: Understanding the Role of Serotonin, Dopamine, Glutamate, and Gaba in Stroke Recovery and Treatment, Central Nervous System Agents in Medicinal Chemistry (2025)
5. Alcohol: Epigenome Alteration and Inter/Transgenerational Effect, Alcohol (2024)
6. Cerebral Inhibition of the H3k9 Methylation Could Ameliorate Blood-Brain Barrier Dysfunction and Neural Damage in Vascular Dementia, Archives of Razi Institute (2024)
7. Exercise-Activated Hepatic Autophagy Combined With Silymarin Is Associated With Suppression of Apoptosis in Rats Subjected to Dexamethasone Induced- Fatty Liver Damage, Molecular Biology Reports (2024)
8. Exercise-Activated Hepatic Autophagy Combined With Silymarin Is Associated With Suppression of Apoptosis in Rats Subjected to Dexamethasone Induced- Fatty Liver Damage, Molecular Biology Reports (2024)
9. Inhibition of Histone Methyltransferase Promotes Cognition and Mitochondrial Function in Vascular Dementia Model, Behavioural Brain Research (2024)
10. Maternal Metformin Administration During the Pre-Gestation Period Improves Transient Cerebral Ischemia Injury in Male Offspring Rats, Advanced Pharmaceutical Bulletin (2024)
11. Neuroprotective Effects of Mk-801 Against Cerebral Ischemia Reperfusion, Heliyon (2024)
12. Preconception Ethanol Exposure Changes Anxiety, Depressive and Checking-Like Behavior and Alter the Expression Levels of Mao-B in Male Offspring, Neurotoxicology and Teratology (2024)
13. Prevention of Glycerol-Induced Acute Kidney Injury by Isoflurane Inhalation in Male Rats, Physiology and Pharmacology (Iran) (2024)
14. Role of Bix01294 in the Intracranial Inhibition of H3k9 Methylation Lessens Neuronal Loss in Vascular Dementia Model, Drug Development Research (2024)
15. The Role of the Jak-Stat Signaling Pathway in the Protective Effects of Hepatic Ischemia Post-Conditioning Against the Injury Induced by Ischemia/Reperfusion in the Rat Liver, Advanced Pharmaceutical Bulletin (2024)
16. Aerobic Training With Naringin Supplementation Improved Spatial Cognition Via H2s Signaling Pathway in Alzheimer’S Disease Model Rats, Experimental Aging Research (2023)
17. Beneficial Effects of Tannic Acid on Comorbid Anxiety in Cecal Ligation and Puncture-Induced Sepsis in Rats and Potential Underlying Mechanisms, Naunyn-Schmiedeberg's Archives of Pharmacology (2023)
18. Deep Brain Stimulation of the Lateral Hypothalamus to Block Morphine Reward: Does the Intensity of Stimulation Matter?, Behavioural Brain Research (2023)
19. Inter/Transgenerational Effects of Drugs of Abuse: A Scoping Review, CNS and Neurological Disorders - Drug Targets (2023)
20. Point-Of-Care Salivary Oxidative and Renal Functional Markers to Assess Kidney Function in Reperfusion-Induced Acute Kidney Injury in Male Rats, Hormone Molecular Biology and Clinical Investigation (2023)
21. Restoring the Firing Activity of Ventral Tegmental Area Neurons by Lateral Hypothalamic Deep Brain Stimulation Following Morphine Administration in Rats, Physiology and Behavior (2023)
22. Sericin Alleviates Motor Dysfunction by Modulating Inflammation and Trkb/Bdnf Signaling Pathway in the Rotenone-Induced Parkinson’S Disease Model, BMC Pharmacology and Toxicology (2023)
23. The Antioxidant and Anti-Inflammatory Effects of Ischemia Post-Conditioning on the Injury Induced by Ischemia/Reperfusion in the Rat Liver, Journal of Veterinary Research (2023)
24. A Single Immediate Use of the Cathodal Transcranial Direct Current Stimulation Induces Neuroprotection of Hippocampal Region Against Global Cerebral Ischemia, Journal of Stroke and Cerebrovascular Diseases (2022)
25. Adipose-Derived Mesenchymal Stem Cells Reduced Transient Cerebral Ischemia Injury by Modulation of Inflammatory Factors and Ampk Signaling, Behavioural Brain Research (2022)
26. Beneficial Effects of Combination Therapy With Testosterone and Hydrogen Sulfide by Reducing Oxidative Stress and Apoptosis: Rat Experimental Varicocele Model, International Journal of Reproductive BioMedicine (2022)
27. Editorial: Covid-19 and Psychological Disorders: From Molecular Basis to Social Impacts and Therapeutic Interventions, Frontiers in Public Health (2022)
28. Effects of Nano-Curcumin on Noise Stress-Induced Hippocampus-Dependent Memory Impairment: Behavioral and Electrophysiological Aspects, Pharmacological Reports (2022)
29. Lactobacillus Rhamnosus R0011 Treatment Enhanced Efficacy of Capecitabine Against Colon Cancer in Male Balb/C Mice, Nutrition and Cancer (2022)
30. Mesenchymal Stem Cells and Their Conditioned Medium As Potential Therapeutic Strategies in Managing Comorbid Anxiety in Rat Sepsis Induced by Cecal Ligation and Puncture, Iranian Journal of Basic Medical Sciences (2022)
31. Protective Effects of Nanocurcumin Against Stress-Induced Deterioration in the Intestine, Stress (2022)
32. The Neuroprotective Effects of Transcranial Direct Current Stimulation on Global Cerebral Ischemia and Reperfusion Via Modulating Apoptotic Pathways, Brain Research Bulletin (2022)
33. Using Dual Polarities of Transcranial Direct Current Stimulation in Global Cerebral Ischemia and Its Following Reperfusion Period Attenuates Neuronal Injury, Metabolic Brain Disease (2022)
34. Dietary Uptake of Salvia Macilenta Extract Improves Nrf2 Antioxidant Signaling Pathway and Diminishes Inflammation and Apoptosis in Amyloid Beta-Induced Rats, Molecular Biology Reports (2021)
35. Highlighting the Protective or Degenerative Role of Ampk Activators in Dementia Experimental Models, CNS and Neurological Disorders - Drug Targets (2021)
36. How Cytosolic Compartments Play Safeguard Functions Against Neuroinflammation and Cell Death in Cerebral Ischemia, Metabolic Brain Disease (2021)
37. Probiotic Lactobacillus Rhamnosus Supplementation Improved Capecitabine Protective Effect Against Gastric Cancer Growth in Male Balb/C Mice, Nutrition and Cancer (2021)
38. Tannic Acid Protects Aged Brain Against Cerebral Hypoperfusion Via Modulation of Nrf2 and Inflammatory Pathways, Neuroscience Letters (2021)
39. Activation of D1-Like Dopamine Receptors Is Involved in the Impairment of Spatial Memory in the Offspring of Morphine-Abstinent Rats, Neuroscience Research (2020)
40. Adipose-Derived Mesenchymal Stem Cells and Conditioned Medium Attenuate the Memory Retrieval Impairment During Sepsis in Rats, Molecular Neurobiology (2020)
41. Comparison of Effects of High-Fat, High-Protein and Low-Calorie Diets on Klotho Gene Expression and Tgf-Β Level in Serum and Liver of Old Male Wistar Rats, Iranian Journal of Nutrition Sciences and Food Technology (2020)
42. Effect of Morphine Exposure on Novel Object Memory of the Offspring: The Role of Histone H3 and Δfosb, Brain Research Bulletin (2020)
43. High-Protein and Low-Calorie Diets Improved the Anti-Aging Klotho Protein in the Rats’ Brain: The Toxic Role of High-Fat Diet, Nutrition and Metabolism (2020)
44. Long-Term Nahs Administration Reduces Oxidative Stress and Apoptosis in a Rat Model of Left-Side Varicocele, Andrologia (2020)
45. Oxidative Stress Enzymes Are Changed in Opioid Abusers and Multidrug Abusers, Journal of Clinical Neuroscience (2020)
46. Repeated Administration of Baclofen Modulates Trpv-1 Channel Expression by Pkc Pathway in Dorsal Root Ganglia of Spinal Cord in Morphine Tolerance Model of Rats, Iranian Biomedical Journal (2020)
47. Toxic Effect of Calcium/Calmodulin Kinase Ii on Anxiety Behavior, Neuronal Firing and Plasticity in the Male Offspring of Morphine-Abstinent Rats, Behavioural Brain Research (2020)
48. Age-Related Difference in Protective Effect of Early Post-Conditioning on Ischemic Brain Injury: Possible Involvement of Map-2/Synaptophysin Role, Metabolic Brain Disease (2019)
49. Morphine Exposure Before Conception Affects Anxiety-Like Behavior and Crf Level (In the Csf and Plasma) in the Adult Male Offspring, Brain Research Bulletin (2019)
50. Nmda Receptors of Blood Lymphocytes Anticipate Cognitive Performance Variations in Healthy Volunteers, Physiology and Behavior (2019)
51. Parental Morphine Exposure Affects Repetitive Grooming Actions and Marble Burying Behavior in the Offspring: Potential Relevance for Obsessive-Compulsive Like Behavior, European Journal of Pharmacology (2019)
52. Parental Morphine Exposure Enhances Morphine (But Not Methamphetamine) Preference and Increases Monoamine Oxidase-B Level in the Nucleus Accumbens, Behavioural Pharmacology (2019)
53. Possible Involvement of Nucleus Accumbens D1-Like Dopamine Receptors in the Morphine-Induced Condition Place Preference in the Offspring of Morphine Abstinent Rats, Life Sciences (2019)
54. Preventing Morphine Reinforcement With High-Frequency Deep Brain Stimulation of the Lateral Hypothalamic Area, Addiction Biology (2019)
55. Radiation-Induced Dual Oxidase Upregulation in Rat Heart Tissues: Protective Effect of Melatonin, Medicina (Lithuania) (2019)
56. Sorafenib-Loaded Pamam Dendrimer Attenuates Liver Fibrosis and Its Complications in Bile-Duct-Ligated Rats, Canadian Journal of Physiology and Pharmacology (2019)
57. Alteration of Dopamine Receptors Subtypes in the Brain of Opioid Abusers: A Postmortem Study in Iran, Neuroscience Letters (2018)
58. Executive Functions Are Related to Serum Testosterone and Basal Metabolism Rate Fluctuation But Not Lymphocyte Dopamine Receptor Expression in the Young Healthy Participants, Physiology and Pharmacology (Iran) (2018)
59. Exercise Training With Concomitant Nitric Oxide Synthase Inhibition Improved Anxiogenic Behavior, Spatial Cognition, and Bdnf/P70s6 Kinase Activation in 20-Month-Old Rats, Applied Physiology# Nutrition and Metabolism (2018)
60. Is the Nociception Mechanism Altered in Offspring of Morphine-Abstinent Rats?, Journal of Pain (2018)
61. Differential Impact of Treadmill Training on Stroke-Induced Neurological Disorders, Brain Injury (2017)
62. Nmda Receptor Adjusted Co-Administration of Ecstasy and Cannabinoid Receptor-1 Agonist in the Amygdala Via Stimulation of Bdnf/Trk-B/Creb Pathway in Adult Male Rats, Brain Research Bulletin (2017)
63. The Involvement of Protein Kinase G Inhibitor in Regulation of Apoptosis and Autophagy Markers in Spatial Memory Deficit Induced by Aβ, Fundamental and Clinical Pharmacology (2016)
64. Ameliorating of Memory Impairment and Apoptosis in Amyloid Β-Injected Rats Via Inhibition of Nitric Oxide Synthase: Possible Participation of Autophagy, Iranian Journal of Pharmaceutical Research (2015)