On the Mechanisms of Taurine in Alleviating Electrocardiographic, Hemodynamic, and Biochemical Parameters Following Aluminum Phosphide Cardiotoxicity Publisher Pubmed



Samadi M^{1, 3} ; Baeeri M³ ; Haghiaminjan H² ; Rahimifard M³ ; Gholami M³ ; Hassani S³ ; Sattari M¹ ; Azarmi Y¹ ; Bameri B³ ; Armandeh M³ ; Hooshangi Shayesteh MR³ ; Eghbal MA^{1, 4} ; Abdollahi M³
Source: Food and Chemical Toxicology Published:2021

Abstract

Background: Aluminum phosphide (AlP) causes severe cardiotoxicity. Taurine has been chosen for the present study because of its positive known effects on cardiac injuries. Method: To evaluate AlP-induced cardiotoxicity, the animals were divided into seven groups, including the control group, the taurine group (500 mg/kg), AlP with LD50 dose, AlP + taurine 20, 50, 100, and 200 mg/kg group. To assess cardiac hemodynamic parameters, Wistar rats received taurine intraperitoneally 60 min after AlP gavage. Cardiac hemodynamic parameters were evaluated for 180 min. To study biochemical parameters, 24 h after AlP treatment, the animals were sacrificed, and heart tissues were collected. Result: ECG, BP, and HR abnormalities of AlP poisoning were improved by taurine treatment. AlP induced biochemical alterations including complexes I and IV activities, the ADP/ATP ratio, mitochondrial membrane potential, cytochrome C release, and oxidative stress biomarkers ameliorated by taurine. Moreover, taurine improved apoptosis, as well as lessened CK-MB and troponin I levels. Also, there were no significant changes between taurine 500 mg/kg and the control group in tests. Conclusion: The present findings showed that taurine could be a possible candidate for AlP cardiotoxicity treatment via the effect on mitochondrial electron transfer chain and maintaining intracellular ATP balance. © 2021 Elsevier Ltd