Pancreas-On-A-Chip Publisher



Mirzababaei S¹ ; Navaeinigjeh M^{1, 2} ; Abdollahi M^{1, 3}
Source: Principles of Human Organs-on-Chips Published:2023

Abstract

Pancreatic islets are responsible for the endocrine functionality of the pancreas, and they play a major role in glucose homeostasis. The disruption of this function leads to diabetes mellitus The lack of suitable in vitro models for islet culture limits the research in this field. One approach to address this issue is developing pancreas models based on microfluidic devices called organ-on-a-chip (OOC). Pancreas-on-a-chip (POC) models provide a 3D perfused environment that improves the viability and functionality of the islets. Besides, integration of sensing modules allows real-time quantitative measurement of islets' secretion that helps assess the quality of islets and their response to different stimuli. Moreover, OOC technology enables the integration of a pancreas model with models of other organs making it possible to study intercommunications of the pancreas with other organs in vitro. Accordingly, POC technology could improve our understanding of pancreatic islets and accelerate diabetic research. © 2023 Elsevier Ltd. All rights reserved.