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Investigation of Properties of Chemically Cross-Linked Silk Nanofibrous Mat As a Nerve Guide Publisher



Ebrahimi M1 ; Ai J1 ; Biazar E2 ; Faridimajidi R3 ; Hajati J4 ; Ebrahimibarough S1 ; Heidari K S5
Authors

Source: Materials Technology Published:2017


Abstract

The aim of this study was to modify a nanofibrous silk mate with a chemically cross-linker. The nanofibrous mats designed by electrospinning method, then were modified using chemically cross-linker of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) in the presence of N-hydroxysuccinimide (NHS). The samples evaluated by microscopic, mechanical analyses, and cell culture assays with Schwann cells. Results of analyses showed a good resilience and compliance with chemically cross-linker. Cellular experiments showed a suitable cell adhesion and growth for the cross-linked mats without any toxicity. This modified mat appears to have the right organisation for testing in vivo special nerve tissue regeneration. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
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