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Silk Fibroin/Hydroxyapatite Composites for Bone Tissue Engineering Publisher Pubmed



Farokhi M1 ; Mottaghitalab F2 ; Samani S3 ; Shokrgozar MA1 ; Kundu SC4 ; Reis RL4 ; Fatahi Y5 ; Kaplan DL6
Authors

Source: Biotechnology Advances Published:2018


Abstract

Silk fibroin (SF) is a natural fibrous polymer with strong potential for many biomedical applications. SF has attracted interest in the field of bone tissue engineering due to its extraordinary characteristics in terms of elasticity, flexibility, biocompatibility and biodegradability. However, low osteogenic capacity has limited applications for SF in the orthopedic arena unless suitably functionalized. Hydroxyapatite (HAp) is a well-established bioceramic with biocompatibility and appropriate for constructing orthopedic and dental substitutes. However, HAp ceramics tend to be brittle which can restrict applications in the repair of load-bearing tissues such as bones. Therefore, blending SF and HAp combines the useful properties of both materials as bone constructs for tissue engineering, the subject of this review. © 2017 Elsevier Inc.
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