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Solvent Effect in Phase Separation for Fabrication of Micropatterned Porous Scaffold Sheets Publisher



Biazar E1 ; Momenzadeh D2 ; Keshel SH3 ; Yousefi F4 ; Shabanian M1 ; Sefidabi F1 ; Sheikholeslami M1
Authors

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2016


Abstract

Cellular orientation control is important for tissue regeneration. Design of oriented structures for cells with suitable features can be used in tissue engineering. One of the methods of cellular orientation with the aim of regenerating which damaged tissues is utilizing oriented biocompatible substrates. This paper reports a one-step method with different solvents to fabricate porous micropatterned polyhydroxybutyrate scaffold sheets. The results indicated that the porosity and pore morphology of the scaffolds are viable with respect to proliferation rate, and a micropattern for cell alignment. Stem cells culturing proved that the scaffold sheets are suitable for cell culturing. Preliminary experiments indicate that the 2-D scaffold sheets are very promising as basis for building 3-D scaffolds. © 2016 Taylor & Francis Group, LLC.
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