Synthesis and Evaluation of Multi-Wall Carbon Nanotube-Paclitaxel Complex As an Anti-Cancer Agent



Ghasemvand F¹ ; Biazar E² ; Tavakolifard S³ ; Khaledian M² ; Rahmanzadeh S¹ ; Momenzadeh D⁴ ; Afroosheh R² ; Zarkalami F² ; Shabannezhad M² ; Tackallou SH⁵ ; Massoudi N⁶ ; Keshel SH^{7, 8}
Source: Gastroenterology and Hepatology from Bed to Bench Published:2016

Abstract

Aim: The aim of this study was to design multi-walled carbon nanotubes (MWCNTs) loaded with paclitaxel (PTX) anti-cancer drug and investigate its anti-cancerous efficacy of human gastric cancer. Background: Carbon nanotubes (CNTs) represent a novel nano-materials applied in various fields such as drug delivery due to their unique chemical properties and high drug loading. Patients and methods: In this study, multi-walled carbon nanotubes (MWCNTs) pre-functionalized covalently with a paclitaxel (PTX) as an anti-cancer drug and evaluated by different analyses including, scanning electron microscope (SEM), particle size analyzer and cellular analyses. Results: A well conjugated of anti-cancer drug on the carbon nanotube surfaces was shown. This study demonstrates that the MWCN-PTX complex is a potentially useful system for delivery of anti-cancer drugs. The flow cytometry, CFU and MTT assay results have disclosed that MWCNT/PTXs might promote apoptosis in MKN-45 gastric adenocarcinoma cell line. Conclusion: According to results, our simple method can be designed a candidate material for chemotherapy. It has presented a few bio-related applications including, their successful use as a nano-carriers for drug transport. © 2016 RIGLD, Research Institute for Gastroenterology and Liver Diseases.