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Fabrication of Poly(Ε-Caprolactone)/Paclitaxel (Core)/Chitosan/Zein/Multi-Walled Carbon Nanotubes/Doxorubicin (Shell) Nanofibers Against Mcf-7 Breast Cancer Publisher



Bahmani E1 ; Dizaji BF2 ; Talaei S3 ; Koushkbaghi S4 ; Yazdani H1 ; Abadi PGS5 ; Akrami M6 ; Shahrousvand M7 ; Jazi FS8 ; Irani M9
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Source: Polymers for Advanced Technologies Published:2023


Abstract

In the present study, paclitaxel (PTX), multi-walled carbon nanotubes (MWCNTs), and doxorubicin (DOX) have been simultaneously doped into the poly(ϵ-caprolactone) (PCL)/chitosan/zein core-shell nanofibers to increase its cytotoxicity for MCF-7 breast cancers killing. The physico-chemical properties of synthesized nanofibers were determined by scanning electron microscope, Fourier-transform infrared spectroscopy, tensile strength, and degradation rate determinations. The in vitro release studies demonstrated the sustained release of drugs from core-shell nanofibrous scaffold. The cytotoxicity and compatibility of core-shell nanofibers were investigated by their treating with MCF-7 breast cancer cells and L929 normal cells, respectively. PCL/PTX/chitosan/zein/MWCNTs/DOX core-shell nanofibers containing 1 wt% MWCNTs, 100 μg ml−1 DOX and 100 μg ml−1 PTX had a high biocompatibility with a 84% MCF-7 cancer cells killing. The in vivo studies revealed the synergic effects of MWCNTs and anticancer drugs on the tumor inhibition. This method could be considered as a new way for developing of MWCNTs loaded-nanofibers for cancer treatment in future. © 2022 John Wiley & Sons Ltd.
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