Apoptosis, Autophagy, and Unfolded Protein Response and Cerebellar Development Publisher



Moosavi MA¹ ; Rahmati M² ; Ashtari N³ ; Alizadeh J³ ; Hashemi M⁴ ; Bathaei SZ⁵ ; Ghavami S^{3, 6}
Source: Contemporary Clinical Neuroscience Published:2017

Abstract

Development is an evolutionary process that is tightly regulated in mammalian species. Several different cascades are involved in different stages of development. Among these mechanisms, apoptosis, autophagy, and unfolded protein response play critical roles in regulation of development by affecting the cell fate. All of these pathways are involved in regulation of cell number via determining the life and death cycles of the cells. In this chapter, we first explain the brief mechanisms that are involved in regulation of apoptosis, autophagy, and unfolded protein response, and later, we briefly describe how these mechanisms play roles in general development. We then discuss the importance of these pathways in regulation of cerebellar development. © 2017, Springer International Publishing AG.