Apoptosis, Autophagy, and Unfolded Protein Response and Cerebellar Development Publisher



Behrrooz AB¹ ; Rahmati M² ; Talaie Z³ ; Ashtari N⁴ ; Alizadeh J⁴ ; Hashemi M⁵ ; Bathaie SZ^{6, 7} ; Moosavi MA^{4, 8, 9, 10, 11, 12} ; Ghavami S^{13, 14}
Source: Contemporary Clinical Neuroscience Published:2023

Abstract

Development is an evolutionary process that is tightly regulated in mammalian species. Several different cascades are involved in various stages of development. Among these mechanisms, apoptosis, autophagy, and unfolded protein response play critical roles in regulating development by affecting cell fate. All of these pathways are involved in the regulation of cell numbers via determining the life and death cycles of the cells. In this chapter, we first explain the brief mechanisms that are involved in the regulation of apoptosis, autophagy, and unfolded protein response, and later, we briefly describe how these mechanisms play roles in general development. We next address the critical role of these pathways in cerebellar development regulation and how they will aid in our knowledge of the processes behind neurodevelopmental disorders. Additionally, we summarize the present findings on neurological symptoms and disorders related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and their linkage to autophagy pathways in the cerebellum. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.