Prokaryotic Toxins Provoke Different Types of Cell Deaths in the Eukaryotic Cells Publisher



Goleij Z¹ ; Mahmoodzadeh Hosseini H¹ ; Amin M² ; Halabian R¹ ; Imani Fooladi AA¹
Source: Toxin Reviews Published:2017

Abstract

Bacterial toxins play major roles in developing infections and can cause diverse morphological and physiological changes via certain biochemical mechanisms leading to cell death. Most of the bacterial toxins induce apoptosis in host cell by intrinsic and extrinsic apoptosis pathways that are caused by intracellular organelle dysfunction and caspase cascade activation. Some of bacterial toxins encourage the programmed necrosis (necroptosis) in mature RBCs. In addition, pore-forming toxins can induce autophagy. Another kind of cell death, the pyroptosis, is induced by Salmonella typhimurium and Pseudomonas aeruginosa and Shigella flexneri and the lethal toxin of Bacillus anthracis. Therefore, recently scientists utilize cytotoxic properties of bacterial toxins for designing novel anti-tumor drugs. © 2017 Informa UK Ltd, trading as Taylor & Francis Group.