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Β Cell and Autophagy: What Do We Know? Publisher



Mohammadimotlagh HR1 ; Sadeghalvad M2 ; Yavari N3 ; Primavera R4 ; Soltani S5 ; Chetty S4 ; Ganguly A4 ; Regmi S4 ; Floyel T6 ; Kaur S6 ; Mirza AH6, 7 ; Thakor AS4 ; Pociot F6, 8 ; Yarani R4, 6
Authors

Source: Biomolecules Published:2023


Abstract

Pancreatic β cells are central to glycemic regulation through insulin production. Studies show autophagy as an essential process in β cell function and fate. Autophagy is a catabolic cellular process that regulates cell homeostasis by recycling surplus or damaged cell components. Impaired autophagy results in β cell loss of function and apoptosis and, as a result, diabetes initiation and progress. It has been shown that in response to endoplasmic reticulum stress, inflammation, and high metabolic demands, autophagy affects β cell function, insulin synthesis, and secretion. This review highlights recent evidence regarding how autophagy can affect β cells’ fate in the pathogenesis of diabetes. Furthermore, we discuss the role of important intrinsic and extrinsic autophagy modulators, which can lead to β cell failure. © 2023 by the authors.
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