Targeting Ferroptosis in Gastrointestinal Tumors: Interplay of Iron-Dependent Cell Death and Autophagy Publisher Pubmed



Safari MH¹ ; Rahimzadeh P² ; Alaei E³ ; Alimohammadi M⁴ ; Esfandiari N⁵ ; Daneshi S⁶ ; Malgard N⁷ ; Farahani N⁸ ; Taheriazam A^{8, 9} ; Hashemi M^{8, 10}
Source: Molecular and Cellular Probes Published:2025

Abstract

Ferroptosis is a regulated cell death mechanism distinct from apoptosis, autophagy, and necroptosis, marked by iron accumulation and lipid peroxidation. Since its identification in 2012, it has developed into a potential therapeutic target, especially concerning GI disorders like PC, HCC, GC, and CRC. This interest arises from the distinctive role of ferroptosis in the progression of diseases, presenting a new avenue for treatment where existing therapies fall short. Recent studies emphasize the promise of focusing on ferroptosis to fight GI cancers, showcasing its unique pathophysiological mechanisms compared to other types of cell death. By comprehending how ferroptosis aids in the onset and advancement of GI diseases, scientists aim to discover novel drug targets and treatment approaches. Investigating ferroptosis in gastrointestinal disorders reveals exciting possibilities for novel therapies, potentially revolutionizing cancer treatment and providing renewed hope for individuals affected by these tumors. © 2025 The Authors