Unveiling the Intersection: Ferroptosis in Influenza Virus Infection Publisher Pubmed



Letafati A¹ ; Taghiabadi Z² ; Ardekani OS³ ; Abbasi S¹ ; Najafabadi AQ⁵ ; Jazi NN³ ; Soheili R⁶ ; Rodrigo R⁷ ; Yavarian J¹ ; Saso L⁸
Source: Virology Journal Published:2024

Abstract

The influenza virus (IFV) imposes a considerable health and economic burden globally, requiring a comprehensive understanding of its pathogenic mechanisms. Ferroptosis, an iron-dependent lipid peroxidation cell death pathway, holds unique implications for the antioxidant defense system, with possible contributions to inflammation. This exploration focuses on the dynamic interplay between ferroptosis and the host defense against viruses, emphasizing the influence of IFV infections on the activation of the ferroptosis pathway. IFV causes different types of cell death, including apoptosis, necrosis, and ferroptosis. IFV-induced ferroptotic cell death is mediated by alterations in iron homeostasis, intensifying the accumulation of reactive oxygen species and promoting lipid peroxidation. A comprehensive investigation into the mechanism of ferroptosis in viral infections, specifically IFV, has great potential to identify therapeutic strategies. This understanding may pave the way for the development of drugs using ferroptosis inhibitors, presenting an effective approach to suppress viral infections. © The Author(s) 2024.