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Advances and Applications of 2-Alkynylbenzaldoxime As a Valuable Synthetic Framework for Synthesizing N-Heterocycles Publisher



Doraghi F1 ; Karimian S2 ; Qareaghaj OH3 ; Larijani B1 ; Mahdavi M1
Authors

Source: Tetrahedron Published:2023


Abstract

2-alkynylbenzaldoxime, a valuable synthetic building block, attracted intense attention in synthetic chemistry for decades. Easily intramolecular cyclization owing to the presence of alkynyl group and subsequent [3 + 2] or [3 + 3] cycloaddition or nucleophilic addition process to construct N-heterocyclic compounds, in particular, indoles and isoquinoline derivatives are the advantages of this useful scaffold. The current review highlights the progress from 2008 until now in the application of 2-alkynylbenzaldoximes in organic synthesis. © 2023 Elsevier Ltd
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