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Potassium T-Butoxide-Promoted Metal-Free Synthesis of Pyrazino[1,2-A]Indoles Via Direct Amidation and Intramolecular Hydroamination Reaction Publisher



Yazzaf R2 ; Adib M2 ; Mahdavi M1
Authors

Source: ChemistrySelect Published:2023


Abstract

A library of pyrazino[1,2-a]indoles has been synthesized via direct amidation and alkyne hydroamination reactions of the molecule produced by indole-2-carboxylic acid and propargyl bromide. The noteworthy features of the present strategy are short reaction time, excellent yields and a broad substrate scope. This cascade reaction also occurred under transition metal-free and ambient conditions as well as operational simplicity. © 2023 Wiley-VCH GmbH.
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