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Recent Advances in Catalytic Transformations of Ortho-Alkynylnaphthols Publisher



Doraghi F1 ; Dostkoh RH2 ; Tavakoli H1 ; Larijani B1 ; Mahdavi M1
Authors

Source: Tetrahedron Published:2025


Abstract

Due to multiple reactive sites, ortho-alkynylnaphthols are extensively used in a diverse range of organic transformations. These precursors can be readily transformed into highly electrophilic vinylidene-quinone methide (VQM), vinyl carbocation, or vinyl radical intermediates towards the synthesis of a large family of auxiliary chiral organic compounds containing biaryls, aryl/heteroaryl and aryl/styrenes. The attractiveness of ortho-alkynylnaphthol from a synthetic point of view has led us to highlight the transformations of this valuable molecule in the presence of various catalytic methods, such as Lewis acidic, Bronsted acidic, Bronsted basic and metal catalytic systems. © 2025 Elsevier Ltd