Magnetic Chitosan-Silk Fibroin Hydrogel/Graphene Oxide Nanobiocomposite for Biological and Hyperthermia Applications Publisher Pubmed



Eivazzadehkeihan R¹ ; Pajoum Z² ; Aghamirza Moghim Aliabadi H³ ; Ganjali F¹ ; Kashtiaray A¹ ; Salimi Bani M⁴ ; Lalebeigi F¹ ; Ziaei Ziabari E⁵ ; Maleki A¹ ; Heravi MM² ; Mahdavi M⁶
Source: Carbohydrate Polymers Published:2023

Abstract

This work represents a biocompatible magnetic nanobiocomposite prepared by the composition of chitosan (CS) hydrogel, silk fibroin (SF), graphene oxide (GO), and Fe3O4 NPs. Terephthaloyl thiourea was applied as a cross-linking agent to cross-link the CS strings. The CS hydrogel/SF/GO/Fe3O4 nanobiocomposite with many characteristics, such as high structural uniformity, thermal stability, biocompatibility, and stability in an aqueous solution. Various characteristics of this novel magnetic nanobiocomposite were distinguished by FT-IR, EDX, FE-SEM, XRD, TGA, and VSM analysis. The FE-SEM images were taken to evaluate the size distribution of the magnetic nanoparticles (MNPs) between 39.9 and 73.3 nm as well. The performance of the prepared nanobiocomposite was assessed by the magnetic fluid hyperthermia process. Under the alternating magnetic field (AMF), the mean value of the specific absorption rate (SAR) was determined at 43.15 w/g. © 2022 Elsevier Ltd