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A Novel Ternary Magnetic Nanobiocomposite Based on Tragacanth-Silk Fibroin Hydrogel for Hyperthermia and Biological Properties Publisher Pubmed

Summary: Can natural gels aid healing? A study found a tragacanth-based nanocomposite with magnetic particles boosts wound healing and cancer therapy with low toxicity. #Nanotechnology #MedicalInnovation

Eivazzadehkeihan R1 ; Mohammadi A1 ; Aghamirza Moghim Aliabadi H2 ; Kashtiaray A1 ; Bani MS3 ; Karimi AH4 ; Maleki A1 ; Mahdavi M5
Authors

Source: Scientific Reports Published:2024


Abstract

This study involves the development of a new nanocomposite material for use in biological applications. The nanocomposite was based on tragacanth hydrogel (TG), which was formed through cross-linking of Ca2+ ions with TG polymer chains. The utilization of TG hydrogel and silk fibroin as natural compounds has enhanced the biocompatibility, biodegradability, adhesion, and cell growth properties of the nanobiocomposite. This advancement makes the nanobiocomposite suitable for various biological applications, including drug delivery, wound healing, and tissue engineering. Additionally, Fe3O4 magnetic nanoparticles were synthesized in situ within the nanocomposite to enhance its hyperthermia efficiency. The presence of hydrophilic groups in all components of the nanobiocomposite allowed for good dispersion in water, which is an important factor in increasing the effectiveness of hyperthermia cancer therapy. Hemolysis and 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assays were conducted to evaluate the safety and efficacy of the nanobiocomposite for in-vivo applications. Results showed that even at high concentrations, the nanobiocomposite had minimal hemolytic effects. Finally, the hyperthermia application of the hybrid scaffold was evaluated, with a maximum SAR value of 41.2 W/g measured in the first interval. © The Author(s) 2024.
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