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Unveiling the Synergy: Biocompatible Alginate-Cellulose Hydrogel Loaded With Silk Fibroin and Zinc Ferrite Nanoparticles for Enhanced Cell Adhesion, and Anti-Biofilm Activity Publisher Pubmed

Summary: Can a gel boost healing? A study found a cellulose-based hydrogel with silk and zinc nanoparticles is safe and fights biofilms, promising for wound healing and drug delivery. #Biomedicine #Nanotechnology

Eivazzadehkeihan R1, 2 ; Nokandeh SM2 ; Aliabadi HAM3, 4 ; Lalebeigi F2 ; Kashtiaray A2 ; Mahdavi M5 ; Sehat S2 ; Cohan RA1 ; Maleki A2
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Source: International Journal of Biological Macromolecules Published:2024


Abstract

Combining a biocompatible hydrogel scaffold with the cell-supportive properties of silk fibroin (SF) and the unique functionalities of ZnFe2O4 nanoparticles creates a promising platform for advanced nanobiomaterials. The research is centered on synthesizing a natural hydrogel using cellulose (Cellul) and sodium alginate (SA) combined with SF and zinc ferrite nanoparticles. A range of analytical and biological assays were conducted to determine the biological and physicochemical properties of the nanobiocomposite. The hemolysis and 2,5-diphenyl-2H-tetrazolium bromide (MTT) assays indicated that the SA-Cellul hydrogel/SF/ZnFe2O4 nanobiocomposite was a biocompatible against human dermal fibroblasts (Hu02) and red blood cells (RBC). In addition, aside from demonstrating outstanding anti-biofilm activity, the nanobiocomposite also promotes the Hu02 cells adhesion, showcasing the synergistic effect of incorporating SF and ZnFe2O4 nanoparticle. These promising results show that this nanobiocomposite has potential applications in various biomedical fields. © 2024 Elsevier B.V.
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