A Novel Magnetic Nanocomposite Based on Alginate-Tannic Acid Hydrogel Embedded With Silk Fibroin With Biological Activity and Hyperthermia Application Publisher Pubmed



Eivazzadehkeihan R¹ ; Farrokhihajiabad F² ; Aliabadi HAM³ ; Ziabari EZ⁴ ; Geshani S² ; Kashtiaray A² ; Bani MS⁵ ; Pishva B² ; Cohan RA¹ ; Maleki A² ; Mahdavi M⁶
Source: International Journal of Biological Macromolecules Published:2023

Abstract

In the current study, sodium alginate (SA) and tannic acid (TA), in the presence of calcium chloride as a cross-linker, were used to fabricate a nanocomposite scaffold. With the addition of silk fibroin (SF), the strength of the synthesized composite was increased. Fe3O4 magnetic nanoparticles (MNPs) led to the usage of this magnetic nanocomposite in hyperthermia applications. Various properties of this scaffold were investigated by field emission scanning electron microscope (FE-SEM), thermogravimetric analysis (TGA), Fourier-transformed infrared (FT-IR), energy dispersive X-Ray (EDX), Vibrating- sample magnetometer (VSM). A hemolytic assay of this magnetic nanocomposite demonstrated that about 100 % of red blood cells (RBCs) survived at a concentration of 2 mg/ml, proving this scaffold is hemocompatible. Furthermore, an MTT assay was utilized to assess the cytotoxicity of the synthesized magnetic nanocomposite. Finally, the hyperthermia behavior of the fabricated magnetic nanocomposite was evaluated, and the specific absorption rate (SAR) was 73.53 W/g. The proposed nanocomposite is a good candidate for wound dressing applications in future studies. © 2022 Elsevier B.V.