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Pectin-Cellulose Hydrogel, Silk Fibroin and Magnesium Hydroxide Nanoparticles Hybrid Nanocomposites for Biomedical Applications Publisher Pubmed



Eivazzadehkeihan R1 ; Ahmadpour F1 ; Aliabadi HAM2, 3 ; Radinekiyan F1 ; Maleki A1 ; Madanchi H4, 5 ; Mahdavi M6 ; Shalan AE7, 8 ; Lancerosmendez S7, 9
Authors

Source: International Journal of Biological Macromolecules Published:2021


Abstract

Natural polymers are at the center of materials development for biomedical and biotechnological applications based on their biocompatibility, low-toxicity and biodegradability. In this study, a novel nanobiocomposite based on cross-linked pectin-cellulose hydrogel, silk fibroin, and Mg(OH)2 nanoparticles was designed and synthesized. After extensive physical-chemical characterization, the biological response of pectin-cellulose/silk fibroin/Mg(OH)2 nanobiocomposite scaffolds was evaluated by cell viability, red blood cells hemolytic and anti-biofilm assays. After 3 days and 7 days, the cell viability of this nanobiocomposite scaffold was 65.5% and 60.5% respectively. The hemolytic effect was below 20%. Furthermore, the presence of silk fibroin and Mg(OH)2 nanoparticles allowed to enhance the anti-biofilm activity, inhibiting the P. aeruginosa biofilm formation. © 2021 Elsevier B.V.
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