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Unconventional Approaches for Synthesis of 2-Substituted Benzothiazoles Publisher



Doraghi F1 ; Edareh MH2 ; Ghanbarlou M1 ; Larijani B1 ; Mahdavi M1
Authors

Source: Organic and Biomolecular Chemistry Published:2025


Abstract

Benzothiazoles are among the most important heterocycles in pharmaceuticals, natural products, and functional materials. Hence, developing direct and sustainable routes by replacing hazardous/toxic thiol reagents with nontoxic reagents for constructing 2-substituted benzothiazoles is of utmost importance. In this review, we have highlighted many synthetic methods for the synthesis of 2-substituted benzothiazoles from different starting materials under transition metal catalysis or metal-free systems. © 2025 The Royal Society of Chemistry.
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