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Thiazole in the Targeted Anticancer Drug Discovery Publisher Pubmed



Ayati A1 ; Emami S2 ; Moghimi S1 ; Foroumadi A1, 3
Authors

Source: Future Medicinal Chemistry Published:2019


Abstract

Cancer is known as one of the main causes of death in the world; and many compounds have been synthesized to date with potential use in cancer therapy. Thiazole is a versatile heterocycle, found in the structure of many drugs in use as well as anticancer agents. This review provides an overview of recent advances in thiazole-bearing compounds as anticancer agents with particular emphasis on their mechanism of action in cancerous cells. Chemical designs, structure-activity relationships and relevant preclinical properties have been comprehensively described. © 2019 Newlands Press.
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