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Reaction of Imidazo[1,2-A]Pyridines With Coumarin-3-Carboxylic Acids: A Domino Michael Addition/Decarboxylation/Oxidation/Annulation Publisher



Kianmehr E1 ; Bari B1 ; Jafarzadeh M1 ; Rostami A2 ; Golshani M3 ; Foroumadi A3
Authors

Source: New Journal of Chemistry Published:2022


Abstract

A facile, metal- and additive-free C-C bond construction between imidazo[1,2-a]pyridines and coumarin-3-carboxylic acids through a decarboxylative Michael addition is reported to achieve an imidazo[1,2-a]pyridin-3-yl-chroman-2-one skeleton. In addition, heterocyclic polyaromatic dibenzoisochromenoimidazo[1,2-a]pyridin-6-ones of value for future medicinal chemistry can be obtained successfully by this procedure through a domino reaction involving Michael addition/decarboxylation/oxidation/C-H bond activation and annulation. © 2022 The Royal Society of Chemistry.
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