Association of Interleukin 1 Gene Cluster and Interleukin 1 Receptor Gene Polymorphisms With Ischemic Heart Failure Publisher Pubmed



Mahmoudi MJ¹ ; Taghvaei M² ; Harsini S³ ; Amirzargar AA^{2, 4} ; Hedayat M⁵ ; Mahmoudi M⁶ ; Nematipour E⁷ ; Farhadi E⁸ ; Esfahanian N² ; Sadr M² ; Nourijelyani K⁹ ; Rezaei N^{3, 4, 10}
Source: Bratislava Medical Journal Published:2016

Abstract

BACKGROUND: Proinfl ammatory cytokines have been known to play a considerable part in the pathomechanisms of chronic heart failure (CHF). Given the importance of proinfl ammatory cytokines in the context of the failing heart, we assessed whether the polymorphisms of interleukin (IL)-1 gene cluster, including IL-1a, IL-1β, and IL-1 receptor antagonist (IL-1RA) and IL-1R gene are predictors of CHF due to ischemic heart disease. METHODS: Forty- three patients with ischemic heart failure were recruited in this study as patients group and compared with 140 healthy unrelated control subjects. Using polymerase chain reaction with sequence-specifi c primers method, the allele and genotype frequency of 5 single nucleotide polymorphisms (SNPs) within the IL- 1a (-889), IL-1β (-511, +3962), IL-1R (psti 1970), and IL-1RA (mspa1 11100) genes were determined.RESULTS: The frequency of the IL-1β -511/C allele was signifi cantly higher in the patient group compared to that in the control group (p = 0.031). The IL-1β (-511) C/C genotype was signifi cantly overrepresented in patients compared to controls (p = 0.022). CONCLUSIONS: Particular allele and genotype in IL-1β gene were overrepresented in patients with ischemic heart failure, possibly affecting the individual susceptibility to this disease (Tab. 1, Ref. 27). Text in PDF www.elis.sk.