Interleukin-4 Cytokine Single Nucleotide Polymorphisms in Kawasaki Disease: A Case-Control Study and a Review of Knowledge Publisher Pubmed



Assari R^{1, 2} ; Aghighi Y³ ; Ziaee V^{1, 2} ; Sadr M⁴ ; Rezaei A⁵ ; Rahmani F^{5, 6} ; Sadr Z⁴ ; Raeeskarami SR⁷ ; Moradinejad MH² ; Rezaei N^{5, 6, 8}
Source: International Journal of Rheumatic Diseases Published:2018

Abstract

Aim: Kawasaki disease (KD) is a systemic vasculitis of medium-sized arteries. High levels of interleukin 4 (IL-4) and the dominance of Th2 cytokines seem to be a key feature in the acute phase of KD. In this study, the role of IL-4 and IL-4R gene polymorphisms were investigated in Iranian children with KD. Methods: Fifty-five patients with KD and 140 healthy subjects as a control group were enrolled in this study. Single nucleotide polymorphisms (SNPs) of IL-4 gene at positions −1098 (rs2243248), −590 (rs2243250) and −33 (rs2070874), as well as IL-4RA gene at position +1902 (rs180275) were assessed in patients and the control group. Results: The C allele and CC genotype of IL-4 gene at position −590 and at position −33 had positive associations and the CT genotype at −590 was negatively associated with KD (odds ratio (95% CI) = 0.04 [0.01–0.09]). The haplotype TCC was more frequent among the patients, while the haplotypes TTT and TTC had a negative association with KD. Conclusion: IL-4 polymorphisms might be associated with KD in an Iranian population. © 2016 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd