Il4 Gene Polymorphisms in Iranian Patients With Autoimmune Hepatitis Publisher Pubmed



Yousefi A¹ ; Mahmoudi E² ; Zare Bidoki A^{3, 6} ; Najmi Varzaneh F^{2, 4} ; Baradaran Noveiry B^{2, 4} ; Sadr M² ; Motamed F¹ ; Najafi M¹ ; Farahmand F¹ ; Rezaei N^{2, 4, 5}
Source: Expert Review of Gastroenterology and Hepatology Published:2016

Abstract

Background: Autoimmune hepatitis (AIH) is a chronic long-lasting hepatocellular inflammation associated with circulating auto antibodies. In addition to the genetic component, several cytokines have been implicated to be involved in AIH. This study was performed to investigate potential associations of AIH with IL4 gene variants.Method: The studied alleles and genotypes included: IL4G/T allele polymorphisms at position-1098 and C/T allele polymorphisms at two positions (-33 and-590) on the IL4 gene, in addition to the A/G allele polymorphisms at position +1902 on the IL4RA gene.Result: The IL4 C allele and CC genotype at position-590 and TT genotype at position-33 had a significantly higher frequency in AIH patients.Conclusion: This study identified the IL4 C allele and CC genotype susceptibility gene in AIH, which will provide better insights into the mechanisms of AIH and potential therapeutic interventions. © 2016 Informa UK Limited.