Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Role of Th1/Th2 Cells and Related Cytokines in Autoimmune Hepatitis Publisher Pubmed



Behfarjam F1 ; Sanati MH1 ; Nasserimoghaddam S2 ; Ataei M1 ; Nikfam S2 ; Jadali Z3
Authors

Source: Turkish Journal of Gastroenterology Published:2017


Abstract

Background/Aims: Dysregulation of T cell response is thought to play an important role in the immunopathogenesis of autoimmune hepatitis. However, no consensus has yet been reached regarding the implications of a distinct T cell subset in the pathogenesis of this progressive liver disease. Therefore, T-bet and GATA-3 expression was examined in patients with autoimmune hepatitis (AIH) and in healthy controls. Moreover, the profile of Th1 (IFN-γ) and Th2 (IL-4) cytokine gene expression was analyzed. Materials and Methods: Levels of mRNA transcripts were measured in peripheral blood mononuclear cells (PBMCs) using a two-step reverse transcription quantitative real-time polymerase chain reaction with SYBR Green. Results: T-bet and IFN-γ mRNA expression was significantly higher in AIH patients compared to healthy controls (p<0.05), whereas no differences were observed for either GATA-3 or IL-4 mRNA expression (p>0.05). Conclusion: Alterations in the Th1/Th2 cell balance may be responsible for both disease progression and the resulting complications. © Copyright 2017 by The Turkish Society of Gastroenterology.
Related Docs
View other Related Docs
1. Il4 Gene Polymorphisms in Iranian Patients With Autoimmune Hepatitis, Expert Review of Gastroenterology and Hepatology (2016)
2. Autoimmune Hepatitis Association With Single Nucleotide Polymorphism of Interleukin-2, But Not Interferon-Gamma, Clinics and Research in Hepatology and Gastroenterology (2018)
3. Association of Interleukin-6 and Interleukin-1 Family Gene Polymorphisms in Autoimmune Hepatitis, Annals of Hepatology (2018)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (5)
Farzaneh Motamed (4)
Other Related Docs
4. T Helper Cell Type-1 Transcription Factor T-Bet Is Down-Regulated in Type 1 Diabetes, Iranian Journal of Allergy# Asthma and Immunology (2016)
5. Th1/Th2 Cytokines in Type 1 Diabetes: Relation to Duration of Disease and Gender, Indian Journal of Endocrinology and Metabolism (2016)
6. Evaluation of Th1/Th2 Lymphocyte Balance in Peripheral Blood Mononuclear Cells of Patients With Hashimoto’S Thyroiditis, Iranian Journal of Public Health (2020)
7. Ifn-Γ Sirna Effectively Knocked Down Ifn-Γ Gene Expression and Reduced Cytokine Secretion in Peripheral Blood Mononuclear Cells of Patients With Autoimmune Hepatitis, Hepatitis Monthly (2018)
8. Disturbed Th1 and Th2 Balance in Patients With Graves' Disease, Minerva Endocrinologica (2016)
9. Differential Expression of Mrna for T-Bet and Gata-3 Transcription Factors in Peripheral Blood Mononuclear Cells of Patients With Vitiligo, Clinical and Experimental Dermatology (2015)
10. Enhanced Th17 Responses in Patients With Autoimmune Hepatitis, Middle East Journal of Digestive Diseases (2019)
11. Association of Il-10 and Tgf-Beta Cytokine Gene Polymorphisms With Autoimmune Hepatitis, Clinics and Research in Hepatology and Gastroenterology (2019)
12. Study of Th1/Th2 Balance in Peripheral Blood Mononuclear Cells of Patients With Alopecia Areata, Acta Microbiologica et Immunologica Hungarica (2015)
13. The Relationship Between Covid-19 and Auto-Immune Hepatitis: An Infectious Agent or Cause for Deterioration?, Archives of Clinical Infectious Diseases (2025)
14. When the Victim Becomes the Villain: Platelets As Drivers of Immune Dysregulation in Itp, Journal of Translational Autoimmunity (2025)
15. Overall Status of Epstein-Barr Virus Infection, Ifn-A, and Tlr-7/9 in Patients With Systemic Lupus Erythematous, Iranian Journal of Immunology (2021)
16. Comparative Transcriptional Signature Analysis of Peripheral Blood Mononuclear Cells in Early Stage of Hepatitis B-Related Hepatocellular Carcinoma, Hepatitis Monthly (2022)
17. Association of Il28b (Ifnl3) Rs12979860 Mrna Levels, Viral Load, and Liver Function Among Hcv Genotype 1A Patients, Gastroenterology and Hepatology from Bed to Bench (2019)
18. The Imbalance of Circulating T Helper Subsets and Regulatory T Cells in Patients With Lrba Deficiency: Correlation With Disease Severity, Journal of Cellular Physiology (2018)
19. T-Bet and Gata-3 Gene Expression in Children With Allergic Asthma and Healthy Controls, Journal of Mazandaran University of Medical Sciences (2017)
20. Immunomodulatory Effect of Calcitriol on Experimental Autoimmune Encephalomyelitis Mice, a Multiple Sclerosis Animal Model, Iranian Journal of Allergy# Asthma and Immunology (2023)