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Transition Metal-Catalyzed Aminocarbonylation Reactions Publisher

Summary: Build amides better? Review covers TM-catalyzed aminocarbonylation with CO/amine for drugs, heterocycles. Study spotlights Pd, Rh, Fe systems. Chem innovation? #OrganicSynthesis #Catalysis

Doraghi F1 ; Hossein Morshedsolouk M1, 2 ; Raisi N3 ; Hosseinifar T2 ; Noori M1 ; Larijani B1 ; Mahdavi M1
Authors

Source: Chemical Record Published:2025


Abstract

Transition-metal-catalyzed aminocarbonylation reactions using low-cost and accessible CO gas as a C1 building block and amine as a nucleophile have been widely used to prepare amides, which are broadly exist in bioactive drugs, natural products, and polymers. This type of reaction has also been applied to construct various biologically active heterocycles. In this review, we highlight aminocarbonylation reactions involving amine and CO under various transition metal catalysis systems (palladium, rhodium, ruthenium, iridium, iron, copper, and cobalt) over the past decade. © 2025 The Chemical Society of Japan and Wiley-VCH GmbH.
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