Modern Metal-Catalyzed and Organocatalytic Methods for Synthesis of Coumarin Derivatives: A Review Publisher Pubmed



Moghadam Farid S¹ ; Seifinoferest B¹ ; Gholamhosseyni M² ; Larijani B¹ ; Mahdavi M¹
Source: Organic and Biomolecular Chemistry Published:2022

Abstract

Coumarin is an important pharmaceutical structural motif, abundantly found in numerous commonly used drugs. Compounds containing this core show a broad spectrum of medicinal properties and biological activities. The increasing importance and wide usages of coumarin derivatives have drawn attention to its synthetic methods, among which metal-catalyzed and organocatalytic methods have proved the most effective. Several metal-catalyzed and/or organocatalytic synthetic strategies for coumarin have been investigated and reported in recent decades. This review focuses on more recent reports on catalysis methods for synthesizing coumarin and coumarin-like structures (including light-mediated methods and nano-catalysts), exploring the mechanistic aspects, simplicity, efficiency, repeatability, and other advantages and disadvantages of these methods. © 2022 The Royal Society of Chemistry