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A Convenient Method for the Synthesis of Chromeno[4,3-B]Pyridines Via Three-Component Reaction Publisher Pubmed



Nikookar H1 ; Moghimi S2 ; Sayahi MH3 ; Mahdavi M4 ; Ranjbar PR1 ; Firoozpour L2 ; Foroumadi A2
Authors

Source: Combinatorial Chemistry and High Throughput Screening Published:2018


Abstract

Aim and Objective: The importance of Chromeno[4,3-b]pyridines in bioactive compounds, highlighted the ongoing research on developing novel methods for the construction of this heterocyclic scaffold. Regarding the advantageous features of multi-component reactions in organic synthesis, we will try to synthesize pyridocoumarins through this method. Materials and Methods: Chromeno[4,3-b]pyridines were conveniently prepared from a threecomponent condensation reaction between 4-hydroxy coumarin, ammonia and ethyl 2,4-dioxo-4- arylbutanoates in refluxing n-propanol. The synthesized compounds were characterized by NMR, IR and Mass spectroscopy. Results: The reaction proceeded through an in situ formed 4-amino coumarin, affording eight new target compounds in good yields. Conclusion: This method introduce a novel approach to ethyl 4-aryl-5-oxo-5H-chromeno[4,3- b]pyridine-2-carboxylate derivatives and allow organic chemists to prepare 4-aminocoumarin in reaction medium. © 2018 Bentham Science Publishers.
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