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Iodine-Catalyzed Tandem Oxidative Coupling Reaction: A One-Pot Strategy for the Synthesis of New Coumarin-Fused Pyrroles Publisher



Yahyavi H1 ; Heravi MM1 ; Mahdavi M2 ; Foroumadi A3, 4
Authors

Source: Tetrahedron Letters Published:2018


Abstract

The simple and facile strategy for the synthesis of 2,3-disubstituted-chromeno[4,3-b]pyrrole-4(1H)-ones has been established. This method describes the Kornblum oxidation reaction of acetophenones, followed by the Knoevenagle treatment of the resulted (het)arylglyoxals with active methylene compounds and consequently iodine-activated Michael type reaction with 4-amino coumarin in a one-pot manner to afford disubstituted chromeno[4,3-b]pyrrole-4(1H)-one derivatives. © 2017