Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Synthesis and Activity Evaluation of New Benzofuran-1,3,4-Oxadiazole Hybrids Against Wood-Degrading Fungi Publisher



Hosseinihashemi SK1 ; Toolabi M2 ; Abedinifar F3 ; Moghimi S3 ; Jalaligoldeh A4 ; Paknejad F5 ; Arabahmadi S6 ; Foroumadi A2, 3
Authors

Source: BioResources Published:2020


Abstract

A series of novel benzofuran-1,3,4-oxadiazole hybrids were synthesized and evaluated as antifungal agents. The synthetic pathway was started from salicylaldehyde, which afforded 5-(substituted benzylthio)-1,3,4-oxadiazole derivatives in moderate to good yields. The compounds were investigated for their antifungal potential against white-rot, Trametes versicolor and brown-rot, Poria placenta and Coniophora puteana fungi at different concentrations (500, 1000 ppm). The obtaining results demonstrated that most of the compounds at 500 ppm concentration did not exhibit acceptable antifungal effects but they had better antifungal activity at 1000 ppm concentration. Compounds 5a, 5c, and 5i showed inhibition percentages of 14.6%, 23.0%, and 14.7%, against the growth of P. placenta and C. puteana, respectively. Among the compounds, the 2-(benzofuran-2-yl)-5-(2,6-difluorobenzyl)thio)-1,3,4-oxadiazole (5h) hybrid was the most active one. © 2020, North Carolina State University.
Related Docs
View other Related Docs
1. Design and Synthesis of New Benzofuran-1,2,3-Triazole Hybrid Preservatives and the Evaluation of Their Antifungal Potential Against White and Brown-Rot Fungi, BioResources (2020)
2. Design, Synthesis, Andin Vitroandin Vivoevaluation of Novel Fluconazole-Based Compounds With Promising Antifungal Activities, ACS Omega (2021)
3. Synthesis, Molecular Docking Study, and Cytotoxic Activity of 3,4-Diaryl-5-(4-Pyridinyl)-1,2,4-Oxadiazole, Medicinal Chemistry (2016)
Experts (# of related papers)
View all Related Experts
Alireza Foroumadi (12)
Loghman Firoozpour (4)
Other Related Docs
4. Baker’S Yeast Promoted One-Pot Synthesis of New 1,2,4-Triazolpyrimido-1,3,4-Oxadiazoles: Investigation of Antioxidant and Antimicrobial Activity, Polycyclic Aromatic Compounds (2022)
5. Design, Synthesis, and Biological Evaluation of 1-(5-(Benzylthio)-1,3,4-Thiadiazol-2-Yl)-3-Phenylurea Derivatives As Anticancer Agents, Medicinal Chemistry Research (2020)
6. 6-Cinnamoyl-4-Arylaminothienopyrimidines As Highly Potent Cytotoxic Agents: Design, Synthesis and Structure-Activity Relationship Studies, European Journal of Medicinal Chemistry (2020)
7. Design and Synthesis of Benzodiazepine-1,2,3-Triazole Hybrid Derivatives As Selective Butyrylcholinesterase Inhibitors, Molecular Diversity (2020)
8. Design, Synthesis and Evaluation of New Azoles As Antifungal Agents: A Molecular Hybridization Approach, Pharmaceutical Chemistry Journal (2016)
9. In Vitro Antifungal Susceptibility Profile of Iranian Fusarium Isolates: Emphasising on the Potent Inhibitory Effect of Efinaconazole Compared to Other Drugs, Mycoses (2023)
10. New Antimicrobial Nitro Heteroaryl-1,3,4-Thiadiazole Derivatives Containing Piperazinyl Benzonitrile Moiety: Synthesis and in Silico Study, Journal of Computational Biophysics and Chemistry (2022)
11. Antifungal Activity, Cytotoxicity and Mechanism of Action of Nitroheteroaryl-1, 3, 4-Thiadiazole Containing N-Benzyl and N-Methoxyethyl Substitution Against Aspergillus Fumigatus, Mediterranean Journal of Infection# Microbes and Antimicrobials (2021)
12. Novel Thiazolotriazolone Derivatives: Design, Synthesis, in Silico Investigation, Analgesic and Anti-Inflammatory Activity, ChemistrySelect (2022)
13. Synthesis of New 2-(5-(5-Nitrofuran-2-Yl)-1,3,4-Thiadiazol-2-Ylimino)Thiazolidin-4-One Derivatives As Anti-Mrsa and Anti-H. Pylori Agents, BMC Chemistry (2022)
14. Antifungal Activity of Capric Acid, Nystatin, and Fluconazole and Their in Vitro Interactions Against Candida Isolates From Neonatal Oral Thrush, Assay and Drug Development Technologies (2020)
15. Potent Activities of Luliconazole, Lanoconazole, and Eight Comparators Against Molecularly Characterized Fusarium Species, Antimicrobial Agents and Chemotherapy (2018)
16. Synthesis and Cholinesterase Inhibitory Activity of New 2-Benzofuran Carboxamide-Benzylpyridinum Salts, Bioorganic Chemistry (2018)
17. History of the Development of Antifungal Azoles: A Review on Structures, Sar, and Mechanism of Action, Bioorganic Chemistry (2020)
18. Synthesis and Docking Study of Novel 4-Thiazolidinone Derivatives As Anti-Gram-Positive and Anti-H. Pylori Agents, Mini-Reviews in Medicinal Chemistry (2019)
19. Thiazole in the Targeted Anticancer Drug Discovery, Future Medicinal Chemistry (2019)
20. Synthesis and in Vitro Anti-Bacterial Activity of 2-(5-Nitro-2-Heteroaryl)-1,3,4-Thiadiazole Derivatives, Journal of Sciences# Islamic Republic of Iran (2020)