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Potent Activities of Luliconazole, Lanoconazole, and Eight Comparators Against Molecularly Characterized Fusarium Species Publisher Pubmed



Abastabar M1 ; Alhatmi AMS2, 3, 4 ; Moghaddam MV5 ; De Hoog GS2, 3 ; Haghani I1 ; Aghili SR1 ; Shokohi T1 ; Hedayati MT1 ; Ghazvini RD6 ; Kachuei R7 ; Rezaeimatehkolaei A8 ; Makimura K9, 10 ; Meis JF3, 11 ; Badalia H12
Authors

Source: Antimicrobial Agents and Chemotherapy Published:2018


Abstract

A collection of clinical (n 47) and environmental (n 79) Fusarium isolates were tested against 10 antifungal drugs, including 2 novel imidazoles. Luliconazole and lanoconazole demonstrated very low geometric mean MIC values of 0.005 and 0.013 g/ml, respectively, compared with 0.51 g/ml for micafungin, 0.85 g/ml for efinaconazole, 1.12 g/ml for natamycin, 1.18 g/ml for anidulafungin, 1.31 g/ml for voriconazole, 1.35 g/ml for caspofungin, 1.9 g/ml for amphotericin B, and 4.08 g/ml for itraconazole. Results show that these drugs are potential candidates for (topical) treatment of skin and nail infections due to Fusarium species. Copyright © 2018 American Society for Microbiology. All Rights Reserved.
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