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Design, Synthesis and Evaluation of New Azoles As Antifungal Agents: A Molecular Hybridization Approach Publisher



Iman M1 ; Peroomian T2 ; Davood A2 ; Amini M3 ; Sardari S4 ; Azerang P4
Authors

Source: Pharmaceutical Chemistry Journal Published:2016


Abstract

Two benzimidazole derivatives and one nitroimidazole derivative were designed using molecular hybridization approach. The designed compounds were synthesized and their in vitro antifungal activities were tested against Candida albicans and Saccharomyces cerevisiae strains. Based on the antifungal activity data, compound 9 containing 2-methyl-5-nitroimidazole moiety proved to be the most potent compound. It was more active than the reference drugs fluconazole and ketoconazole against S. cerevisiae. © 2016, Springer Science+Business Media New York.
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