Quinoline-Based Imidazole-Fused Heterocycles As New Inhibitors of 15-Lipoxygenase

Quinoline-Based Imidazole-Fused Heterocycles As New Inhibitors of 15-Lipoxygenase Publisher Pubmed

Dianat S¹ ; Moghimi S² ; Mahdavi M³ ; Nadri H⁴ ; Moradi A⁴ ; Firoozpour L³ ; Emami S⁵ ; Mouradzadegun A¹ ; Shafiee A² ; Foroumadi A^{2, 3}

Source: Journal of Enzyme Inhibition and Medicinal Chemistry Published:2016

Abstract

A series of 2-chloro-quinoline-based imidazopyridines 6a–l and imidazothiazoles 6m–o bearing a bulky alkylamine side chain were synthesized as soybean 15-LOX inhibitors. The target compounds 6a–o were prepared via one-pot reaction of 2-chloroquinoline-3-carbaldehyde (3), heteroaromatic amidine 4, and alkyl isocyanides 5, in the presence of NH4Cl. All compounds showed significant anti-15-LOX activity (IC50 values ≤40 μM). Among the title compounds, the imidazo[2,1-b]thiazole derivative 6n bearing a tert-butylamine moiety showed the highest activity against soybean 15-LOX enzyme. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

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Mohammad Mahdavi (12)

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Style	Citing Format
MLA	Dianat S, et al.. "Quinoline-Based Imidazole-Fused Heterocycles As New Inhibitors of 15-Lipoxygenase." Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 31, no. , 2016, pp. 205-209.
APA	Dianat S, Moghimi S, Mahdavi M, Nadri H, Moradi A, Firoozpour L, Emami S, Mouradzadegun A, Shafiee A, Foroumadi A (2016). Quinoline-Based Imidazole-Fused Heterocycles As New Inhibitors of 15-Lipoxygenase. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(), 205-209.
Chicago	Dianat S, Moghimi S, Mahdavi M, Nadri H, Moradi A, Firoozpour L, Emami S, Mouradzadegun A, Shafiee A, Foroumadi A. "Quinoline-Based Imidazole-Fused Heterocycles As New Inhibitors of 15-Lipoxygenase." Journal of Enzyme Inhibition and Medicinal Chemistry 31, no. (2016): 205-209.
Harvard	Dianat S et al. (2016) 'Quinoline-Based Imidazole-Fused Heterocycles As New Inhibitors of 15-Lipoxygenase', Journal of Enzyme Inhibition and Medicinal Chemistry, 31(), pp. 205-209.
Vancouver	Dianat S, Moghimi S, Mahdavi M, Nadri H, Moradi A, Firoozpour L, et al.. Quinoline-Based Imidazole-Fused Heterocycles As New Inhibitors of 15-Lipoxygenase. Journal of Enzyme Inhibition and Medicinal Chemistry. 2016;31():205-209.
BibTex	@article{ author = {Dianat S and Moghimi S and Mahdavi M and Nadri H and Moradi A and Firoozpour L and Emami S and Mouradzadegun A and Shafiee A and Foroumadi A}, title = {Quinoline-Based Imidazole-Fused Heterocycles As New Inhibitors of 15-Lipoxygenase}, journal = {Journal of Enzyme Inhibition and Medicinal Chemistry}, volume = {31}, number = {}, pages = {205-209}, year = {2016} }
RIS	TY - JOUR AU - Dianat S AU - Moghimi S AU - Mahdavi M AU - Nadri H AU - Moradi A AU - Firoozpour L AU - Emami S AU - Mouradzadegun A AU - Shafiee A AU - Foroumadi A TI - Quinoline-Based Imidazole-Fused Heterocycles As New Inhibitors of 15-Lipoxygenase JO - Journal of Enzyme Inhibition and Medicinal Chemistry VL - 31 IS - SP - 205 EP - 209 PY - 2016 ER -

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