Synthesis and Biological Evaluation of 5-Benzylidenerhodanine-3-Acetic Acid Derivatives As Ache and 15-Lox Inhibitors

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Synthesis and Biological Evaluation of 5-Benzylidenerhodanine-3-Acetic Acid Derivatives As Ache and 15-Lox Inhibitors Publisher Pubmed

Shafii N¹ ; Khoobi M² ; Amini M² ; Sakhteman A³ ; Nadri H³ ; Moradi A³ ; Emami S⁴ ; Saeedian Moghadam E² ; Foroumadi A² ; Shafiee A^{1, 2}

Source: Journal of Enzyme Inhibition and Medicinal Chemistry Published:2015

Abstract

A series of 5-benzylidenerhodanine-3-acetamides bearing morpholino-, 4-arylpiperazinyl-, or 4-benzylpiperidinyl- moieties were synthesized and their inhibitory activities against acetylcholinesterase (AChE) were evaluated. Alteration of amide part and substitution on the benzylidene moiety resulted in change of anti-AChE activity. The most active compound was the 1-benzylpiperidinyl derivative containing 4-(dimethylamino)benzylidene scaffold. Notably, the intermediate compounds, namely 5-arylidene-rhodanine-3-acetic acids (3), showed mild inhibitory activity against 15-lipoxygenase (15-LOX), while the final compound 4 showed no activity against 15-LOX. © 2015 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted.

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Style	Citing Format
MLA	Shafii N, et al.. "Synthesis and Biological Evaluation of 5-Benzylidenerhodanine-3-Acetic Acid Derivatives As Ache and 15-Lox Inhibitors." Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 30, no. 3, 2015, pp. 389-395.
APA	Shafii N, Khoobi M, Amini M, Sakhteman A, Nadri H, Moradi A, Emami S, Saeedian Moghadam E, Foroumadi A, Shafiee A (2015). Synthesis and Biological Evaluation of 5-Benzylidenerhodanine-3-Acetic Acid Derivatives As Ache and 15-Lox Inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 30(3), 389-395.
Chicago	Shafii N, Khoobi M, Amini M, Sakhteman A, Nadri H, Moradi A, Emami S, Saeedian Moghadam E, Foroumadi A, Shafiee A. "Synthesis and Biological Evaluation of 5-Benzylidenerhodanine-3-Acetic Acid Derivatives As Ache and 15-Lox Inhibitors." Journal of Enzyme Inhibition and Medicinal Chemistry 30, no. 3 (2015): 389-395.
Harvard	Shafii N et al. (2015) 'Synthesis and Biological Evaluation of 5-Benzylidenerhodanine-3-Acetic Acid Derivatives As Ache and 15-Lox Inhibitors', Journal of Enzyme Inhibition and Medicinal Chemistry, 30(3), pp. 389-395.
Vancouver	Shafii N, Khoobi M, Amini M, Sakhteman A, Nadri H, Moradi A, et al.. Synthesis and Biological Evaluation of 5-Benzylidenerhodanine-3-Acetic Acid Derivatives As Ache and 15-Lox Inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 2015;30(3):389-395.
BibTex	@article{ author = {Shafii N and Khoobi M and Amini M and Sakhteman A and Nadri H and Moradi A and Emami S and Saeedian Moghadam E and Foroumadi A and Shafiee A}, title = {Synthesis and Biological Evaluation of 5-Benzylidenerhodanine-3-Acetic Acid Derivatives As Ache and 15-Lox Inhibitors}, journal = {Journal of Enzyme Inhibition and Medicinal Chemistry}, volume = {30}, number = {3}, pages = {389-395}, year = {2015} }
RIS	TY - JOUR AU - Shafii N AU - Khoobi M AU - Amini M AU - Sakhteman A AU - Nadri H AU - Moradi A AU - Emami S AU - Saeedian Moghadam E AU - Foroumadi A AU - Shafiee A TI - Synthesis and Biological Evaluation of 5-Benzylidenerhodanine-3-Acetic Acid Derivatives As Ache and 15-Lox Inhibitors JO - Journal of Enzyme Inhibition and Medicinal Chemistry VL - 30 IS - 3 SP - 389 EP - 395 PY - 2015 ER -

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